A novel tuberculosis DNA vaccine in a HIV - 1 p 24 protein backbone confers 1 protection against Mycobacterium Tuberculosis and simultaneously elicits robust 2 humoral and cellular responses to HIV - 1 3
نویسندگان
چکیده
1 protection against Mycobacterium Tuberculosis and simultaneously elicits robust 2 humoral and cellular responses to HIV-1 3 Xiaoman Li, 1 Wei Xu, 1 and Sidong Xiong 1, 2 * 4 Institute for Immunobiology and Department of Immunology, Shanghai Medical College, 5 Fudan University, Shanghai 200032, People's Republic of China, 1 and Jiangsu Key 6 Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, 7 Soochow University, Suzhou, People's Republic of China 2 8 ∗ Corresponding author. Mailing address: Institute for Immunobiology and Department 9 of Immunology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, 10 Shanghai, People's Republic of China. Phone: 086-21-54237749. Fax: 086-21-54237749. 11 E-mail: [email protected]. 12 Running title: Protective efficacy of pP24-Mtb tuberculosis vaccine 13 Copyright © 2012, American Society for Microbiology. All Rights Reserved. Clin. Vaccine Immunol. doi:10.1128/CVI.05700-11 CVI Accepts, published online ahead of print on 29 March 2012
منابع مشابه
A novel tuberculosis DNA vaccine in an HIV-1 p24 protein backbone confers protection against Mycobacterium tuberculosis and simultaneously elicits robust humoral and cellular responses to HIV-1.
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major infectious disease worldwide. Moreover, latent M. tuberculosis infection is more likely to progress to active TB and eventually leads to death when HIV infection is involved. Thus, it is urgent to develop a novel TB vaccine with immunogenicity to both M. tuberculosis and HIV. In this study, four uncharacterized T cell epitop...
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